人类1号染色体上TATAAA基序的不可约遗传标记现象
Phenomenon of irreducible genetic markers for TATAAA motifs in human chromosome 1
摘要：
众所周知，一般的转录因子（GTF）特异性识别正确的TATA盒，将它们与许多其他的TATA盒区分开来。采用确定性分析（规则的数学理论）的原则，我们分析了人类1号染色体DNA序列的片段，并确定了最接近TATAAA基序的特定遗传标记（IG标记=不可约遗传标记）。IG标记物能够确定所研究的DNA片段内任何TATAAA基序的确切位置。基于我们的数据，我们假设GTF通过IG标记识别“真实”转录起始TATA盒。这里描述的数学方法是通用的，并且可以用于找到IG标记，其将像全球导航卫星系统一样提供较大DNA序列内容内的任何不同序列基序的特定位置。
英文摘要：
It is well known that the general transcription factors (GTF) specifically recognize correct TATA boxes, distinguishing them from many others. Employing the principles of determinacy analysis (mathematical theory of rules) we analyzed a fragment of human chromosome 1 DNA sequence and identified specific genetic markers (IG-markers = Irreducible Genetic markers) in the nearest proximity to TATAAA motifs. The IG-markers enable determining the exact location of any TATAAA motif within the investigated DNA fragment. Based on our data we hypothesize that the GTF recognize the «true» transcriptional start TATA box by means of IG-markers. The math method described here is universal and can be used to find IG-markers that will provide, like a global navigation satellite system, for the specific location of any distinct sequence motif within larger DNA sequence content.
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