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arXiv 1203.2199q-bio.QMmath-phmath.MPphysics.bio-ph
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细胞膜中的临界Casimir力

Critical Casimir forces in cellular membranes

Benjamin B. Machta, Sarah L. Veatch, James P. Sethna

摘要:

最近的实验表明,活细胞的膜被调谐到接近2D伊辛普适性类中的可分辨性临界点。我们建议,这种接近活细胞中的临界性的一个作用是提供一个管道相对较长的临界卡西米尔部队。利用共形场论的技术,我们计算了膜结合夹杂物介导的局部相互作用与组成序参量之间的平均力的潜力。我们验证这些计算使用蒙特卡洛,我们也比较临界和非临界的结果。我们的研究结果表明,膜结合蛋白质的经验弱,但长距离的部队介导的关键组成波动的活细胞的质膜。

英文摘要:

Recent experiments suggest that membranes of living cells are tuned close to a miscibility critical point in the 2D Ising universality class. We propose that one role for this proximity to criticality in live cells is to provide a conduit for relatively long-ranged critical Casimir forces. Using techniques from conformal field theory we calculate potentials of mean force between membrane bound inclusions mediated by their local interactions with the composition order parameter. We verify these calculations using Monte-Carlo where we also compare critical and off-critical results. Our findings suggest that membrane bound proteins experience weak yet long range forces mediated by critical composition fluctuations in the plasma membranes of living cells.

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