对称性对抗原变异动力学的影响
The effects of symmetry on the dynamics of antigenic variation
摘要：
在病原体的动力学及其与宿主免疫系统的相互作用的研究中，与病原体相关的抗原变体的结构起着重要作用。使用的例子，在疟疾的抗原变异模型，我们展示了有多少所观察到的动态制度可以解释在不同的抗原变体之间的相互作用的对称性。这项分析的结果是相当通用的，并有更广泛的影响，了解其他寄生虫的免疫逃逸的动态，以及多株疾病的动态。
英文摘要：
In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen. Using the example of a model of antigenic variation in malaria, we show how many of the observed dynamical regimes can be explained in terms of the symmetry of interactions between different antigenic variants. The results of this analysis are quite generic, and have wider implications for understanding the dynamics of immune escape of other parasites, as well as for the dynamics of multi-strain diseases.
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