通过手性放大的同手性寡肽：用共聚模型解释实验数据
Homochiral oligopeptides by chiral amplification: Interpretation of experimental data with a copolymerization model
摘要：
我们提出了一个微分速率方程模型的基础上的一个简单的共聚方案，其中的对映体被添加到，或从，同手性或异手性链（可逆逐步等键增长或解离）的手性聚合。该模型是建立封闭系统，并考虑到相应的热力学约束所隐含的可逆单体附件，同时遵守恒定的质量约束。在其最简单的形式，该模型取决于一个单一的可变速率常数，最大链长N，和初始浓度。我们已经将模型拟合到Rehovich小组关于寡肽的晶格控制手性扩增的实验数据。我们发现，在所有的化学系统中，除了一个，该模型拟合测得的相对丰度的寡肽具有更高程度的相关性比从一个纯粹的随机聚合过程。
英文摘要：
We present a differential rate equation model of chiral polymerization based on a simple copolymerization scheme in which the enantiomers are added to, or removed from, the homochiral or heterochiral chains (reversible stepwise isodesmic growth or dissociation). The model is set up for closed systems and takes into account the corresponding thermodynamic constraints implied by the reversible monomer attachments, while obeying a constant mass constraint. In its simplest form, the model depends on a single variable rate constant, the maximum chain length N, and the initial concentrations. We have fit the model to the experimental data from the Rehovot group on lattice-controlled chiral amplification of oligopeptides. We find in all the chemical systems employed except for one, that the model fits the measured relative abundances of the oligopetides with higher degrees of correlation than from a purely random polymerization process.
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