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arXiv 1202.2045stat.MEmath.STstat.TH
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精确多元检验--一种新的有效的受控模型选择原则

Exact Multivariate Tests - A New Effective Principle of Controlled Model Choice

Juergen Laeuter, Maciej Rosolowski, Ekkehard Glimm

摘要:

应用高维测试来找到相关的变量集和相关模型。如果通过分析乘积矩阵的和来选择变量并执行相应的均值检验,则存在超过第一类标称误差的危险。本文对著名的多元检验作了新的数学解释,使第一类组合检验和选择过程的误差更易于保持。平均值的零假设由个体评分响应的分布球度假设替代。因此,在没有太强限制的情况下,模型选择是可能的。该方法适用于所有线性多变量设计。生物信息学的一个例子说明了这一点:选择基因集以比较B细胞淋巴瘤患者组。

英文摘要:

High-dimensional tests are applied to find relevant sets of variables and relevant models. If variables are selected by analyzing the sums of products matrices and a corresponding mean-value test is performed, there is the danger that the nominal error of first kind is exceeded. In the paper, well-known multivariate tests receive a new mathematical interpretation such that the error of first kind of the combined testing and selecting procedure can more easily be kept. The null hypotheses on mean values are replaced by hypotheses on distributional sphericity of the individual score responses. Thus, model choice is possible without too strong restrictions. The method is presented for all linear multivariate designs. It is illustrated by an example from bioinformatics: The selection of gene sets for the comparison of groups of patients suffering from B-cell lymphomas.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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