人体支气管气道组织的动力学特性
Dynamic Properties of Human Bronchial Airway Tissues
摘要：
用压缩法测量了人支气管气道组织的杨氏模量和动态力模量。本研究建立了一套简单、低成本的生物软质材料拉伸强度测试系统。力-距离测量是在从患有COPD的肺癌患者捐赠的手术切除的肺中解剖的支气管气道壁、软骨和粘膜上进行的。杨氏模量估计从卸载力-位移曲线的初始斜率和动态力模量（存储和损失）在低频率（从3到45 Hz）下测量。所有样品在室温下保存在PBS溶液中，并在手术后4小时内进行测量。人支气管气道壁的杨氏模量范围在0.17和1.65 MPa之间，软骨的范围在0.25至1.96 MPa之间，粘膜的范围在0.02至0.28 MPa之间。储能模量随频率变化0.10 MPa，而损耗模量随频率从0.08 MPa增加到0.35 MPa。频率依赖的动态力模量也比较了不同的应变率。
英文摘要：
Young's Modulus and dynamic force moduli were measured on human bronchial airway tissues by compression. A simple and low-cost system for measuring the tensile-strengh of soft bio-materials has been built for this study. The force-distance measurements were undertaken on the dissected bronchial airway walls, cartilages and mucosa from the surgery-removed lungs donated by lung cancer patients with COPD. Young's modulus is estimated from the initial slope of unloading force-displacement curve and the dynamic force moduli (storage and loss) are measured at low frequency (from 3 to 45 Hz). All the samples were preserved in the PBS solution at room temperature and the measurements were perfomed within 4 hours after surgery. Young's modulus of the human bronchial airway walls are fond ranged between 0.17 and 1.65 MPa, ranged between 0.25 to 1.96 MPa for cartilages, and between 0.02 to 0.28 MPa for mucosa. The storage modulus are found varying 0.10 MPa with frequency while the loss modulus are found increasing from 0.08 to 0.35 MPa with frequency. The frequency-dependent dynamic force moduli are also compared with different strain rates.
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