声流对高强度聚焦超声组织加热的影响
Effect of acoustic streaming on tissue heating due to high-intensity focused ultrasound
摘要：
研究了高强度聚焦超声（HIFU）消融肝脏肿瘤过程中血管和聚焦位置对温度分布的影响。采用三维声-热-液力偶合器模型计算肝癌区域的温度场。该模型是基于线性Westerpyruvate和生物热方程以及非线性纳维-斯托克斯方程的肝实质和血管。在目前的HIFU模拟研究中也考虑了声流的影响。研究了不同血管直径和焦点位置。我们发现，从这个三维数值研究，在大血管的对流冷却和声流可以改变相当大的温度场和热损伤附近的血管。如果血管位于波束宽度内，则应考虑声流和血流冷却效应。在靠近血管壁的区域，考虑声流效应和不考虑声流效应的情况下的预测温差为54%。当考虑声流效应时，坏死体积可减少约30%。
英文摘要：
The influences of blood vessels and focused location on temperature distribution during high-intensity focused ultrasound (HIFU) ablation of liver tumors is studied. A three-dimensional acoustics-thermal-fluid coupling model is employed to compute the temperature field in the hepatic cancerous region. The model is based on the linear Westervelt and bioheat equations as well as the nonlinear Navier-Stokes equations for the liver parenchyma and blood vessels. The effect of acoustic streaming is also taken into account in the present HIFU simulation study. Different blood vessel diameters and focal point locations were investigated. We found from this three-dimensional numerical study that in large blood vessels both the convective cooling and acoustic streaming can change considerably the temperature field and the thermal lesion near blood vessels. If the blood vessel is located within the beam width, both acoustic streaming and blood flow cooling effects should be taken into account. The predicted temperature difference for the cases considered with and without acoustic streaming effect is 54 % in regions close to the vessel wall. The necrosed volume can be reduced about 30 %, when taking into account acoustic streaming effect.
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