银依赖（在硅片）的方法意味着一个确定性的动力学稳态记忆细胞周转
Ag-dependent (in silico) approach implies a deterministic kinetics for homeostatic memory cell turnover
摘要：
Verhulst类数学模型已被用于研究几个复杂的生物学问题，如免疫记忆平衡和哺乳动物细胞介导的免疫。这两个过程的调节机制仍然没有得到充分的理解。在最近的一篇论文中，Choo等人[J. Immunol.，第185页。3436-44，2010]，使用Ag-独立方法从一些经验数据定量分析记忆细胞更新，并得出结论，免疫稳态表现为随机性，而不是确定性。在这里提出的文件中，我们使用了在silico银依赖的方法来模拟抗原突变的过程，并研究其对记忆动力学的影响。我们的研究结果表明，一个确定性动力学的稳态平衡，这与Choo等人的发现相矛盾。因此，我们的计算是一个指示，一个更广泛的经验协议研究的稳态营业额应考虑。
英文摘要：
Verhulst-like mathematical modeling has been used to investigate several complex biological issues, such as immune memory equilibrium and cell-mediated immunity in mammals. The regulation mechanisms of both these processes are still not sufficiently understood. In a recent paper, Choo et al. [J. Immunol., v. 185, pp. 3436-44, 2010], used an Ag-independent approach to quantitatively analyze memory cell turnover from some empirical data, and concluded that immune homeostasis behaves stochastically, rather than deterministically. In the paper here presented, we use an in silico Ag-dependent approach to simulate the process of antigenic mutation and study its implications for memory dynamics. Our results have suggested a deterministic kinetics for homeostatic equilibrium, what contradicts the Choo et al. findings. Accordingly, our calculations are an indication that a more extensive empirical protocol for studying the homeostatic turnover should be considered.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
