蛋白质长度对生物体倍性水平和环境耐受性的影响
The Effect of Protein Length on the Ploidy Level and Environmental Tolerance of Organisms
摘要：
本文总结了以往的工作联系蛋白质聚集的杂合性的生物体。它还引用了文献，表明物种的形态复杂性与其蛋白质长度之间的相关性。这两个发现结合起来形成了一个理论，可能解释生物体的倍性水平。生物体可以利用杂合性来抑制蛋白质聚集。因此，复杂的生物体往往是二倍体，因为它们倾向于合成长的、易于聚集的蛋白质。另一方面，简单的生物体往往是单倍体，因为它们合成的短蛋白质不太容易聚集。该理论也可以解释与不同倍性水平的生物相关的生态趋势。还开发了两个数学模型，可以解释：1）蛋白质聚集如何导致截短选择，保持自然群体中的许多多态性，和2）蛋白质周转，代谢效率和杂种优势之间的关系。
英文摘要：
This paper summarizes previous work linking protein aggregation to the heterozygosity of organisms. It also cites the literature showing a correlation between species' morphological complexity and the lengths of their proteins. These two findings are combined to form a theory that may potentially explain the ploidy levels of organisms. Organisms can employ heterozygosity to inhibit protein aggregation. Hence, complex organisms tend to be diploid because they tend to synthesize long, aggregation-prone proteins. On the other hand, simple organisms tend to be haploid because they synthesize short proteins that are less prone to aggregation. The theory may also explain ecological trends associated with organisms of different ploidy level. Two mathematical models are also developed that may explain: 1) how protein aggregation results in truncation selection that maintains numerous polymorphisms in natural populations, and 2) the relationship between protein turnover, metabolic efficiency, and heterosis.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
