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arXiv 1109.5474cond-mat.softphysics.bio-phphysics.comp-phq-bio.BM
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富含胞嘧啶的DNA链解折叠机制中隐藏的复杂性

Hidden complexities in the unfolding mechanism of a cytosine-rich DNA strand

Jens Smiatek, Daniel Janssen-Mueller, Rudolf Friedrich, Andreas Heuer

摘要:

我们通过分子动力学模拟研究了富含胞嘧啶的DNA发夹结构的解折叠途径。我们的研究结果表明,在展开过程中存在一个隐藏的复杂性。我们表明,这种复杂的行为是由于非随机的贡献,有一个重要的影响描述的动态集体变量。

英文摘要:

We investigate the unfolding pathway of a cytosine-rich DNA hairpin structure via Molecular Dynamics simulations. Our results indicate a hidden complexity present in the unfolding process. W e show that this complex behavior arises due to non-stochastic contributions which have an important impact on the description of the dynamics in terms of collective variables.

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