生物分子信号转导中的非平衡相变
Non-equilibrium phase transitions in biomolecular signal transduction
摘要：
我们研究了生物分子信号转导级联的可靠开关机制。稳定的磷酸化状态是由蛋白质群体中系统大小的协同效应产生的，尽管任何分子的磷酸化状态转换（通过其实现开关）都是高度随机的。开关的出现是由主方程描述的能量驱动的耗散系统中的非平衡相变。我们使用算子和功能积分方法从反应扩散理论解决的相结构，噪声谱，逃逸轨迹和第一次通过时间的一类最小模型的开关，显示如何所有的关键属性开关行为可以计算在一个统一的框架内。
英文摘要：
We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of any molecule, by means of which the switch is implemented, are highly stochastic. The emergence of switching is a nonequilibrium phase transition in an energetically driven, dissipative system described by a master equation. We use operator and functional integral methods from reaction-diffusion theory to solve for the phase structure, noise spectrum, and escape trajectories and first-passage times of a class of minimal models of switches, showing how all critical properties for switch behavior can be computed within a unified framework.
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