利用非互补性和几何不相容性制备人工DNA晶格
Artificial DNA Lattice Fabrication by Non-Complementarity and Geometrical Incompatibility
摘要：
DNA纳米结构的制造主要遵循两个基本规则。首先，DNA寡核苷酸通过互补碱基序列之间的沃森-克里克碱基配对规则相互结合。其次，DNA寡核苷酸的几何相容性必须匹配以形成晶格。在这里，我们提出了一个制造计划的DNA纳米结构与非互补和/或几何不相容的DNA寡核苷酸，这与传统的DNA结构的创建规则相矛盾。DNA晶格尺寸的定量分析进行了验证，这对应于算法自组装中的错误的不利的绑定发生。对这些类型的结合的进一步研究可能会对DNA纳米结构自组装的确切机制有更多的了解。
英文摘要：
Fabrication of DNA nanostructures primarily follows two fundamental rules. First, DNA oligonucleotides mutually combine by Watson-Crick base pairing rules between complementary base sequences. Second, the geometrical compatibility of the DNA oligonucleotide must match for lattices to form. Here we present a fabrication scheme of DNA nanostructures with non-complementary and/or geometrically incompatible DNA oligonucleotides, which contradicts conventional DNA structure creation rules. Quantitative analyses of DNA lattice sizes were carried out to verify the unfavorable binding occurrences which correspond to errors in algorithmic self-assembly. Further studies of these types of bindings may shed more light on the exact mechanisms at work in the self-assembly of DNA nanostructures.
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