DNA点突变氢键的量子理论
Quantum theory of hydrogen key of point mutation in DNA
摘要：
本文提出了DNA双螺旋复制时氢原子在两个互补核苷酸碱基间分布的量子理论。它基于两种质子隧穿机制：具有自发声子辐射的Andreev-Meyerovich机制和声子散射的Kagan-Maximov（Flynn-Stoneham）机制。根据所提出的模型，质子在浅势阱（点突变形式）中的位置概率与温度成正比。结果表明，随着复制速度的增加，点突变概率降低。
英文摘要：
Quantum theory of hydrogen atoms distribution between two complementary nucleotide bases in DNA double helix at moment of replication has been proposed in this work. It bases on two mechanisms of proton tunneling: the Andreev-Meyerovich mechanism with spontaneous phonon radiation and the Kagan-Maximov (Flynn-Stoneham) mechanism at phonon scattering. According to the presented model, the probability of proton location in shallow potential well (point mutation form) is directly proportional to temperature. It was shown that the point mutation probability decreases with increasing replication velocity.
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