7个物种在整个生命周期中的海马神经发生建模
Modelling hippocampal neurogenesis across the lifespan in seven species
摘要：
这项研究的目的是估计在整个生命周期中添加到齿状回的新细胞和神经元的数量，并比较不同物种之间与年龄相关的神经发生下降的速度。来自小鼠（Mus musculus）、大鼠（Rattus norvegicus）、小刺猬（Echinops telfairi）、猕猴（Macaca mulatta）、绒猴（Callithrix jacchus）、树鼩（Tupaia belangeri）和人类（Homo sapiens）的数据来自发表在14篇不同论文中的21个数据集。方差分析，指数，威布尔和功率模型拟合的数据，以确定最好的描述年龄和神经发生之间的关系。指数模型提供了适当的拟合，并用于估计相关参数。神经发生的减少率与物种寿命相关（r = 0.769，p = 0.043），但与体重或基础代谢率无关。在出生后添加到小鼠齿状回的所有细胞中，只有8.5%（95%CI = 1.0%至14.7%）的这些细胞将在中年后添加。此外，仅有5.7%（95% CI = 0.7%至9.9%）的现有细胞群从中年开始转变。因此，在动物的大部分生命中，相对较少的新细胞被添加，并且其中只有一部分会成熟为功能性神经元。
英文摘要：
The aim of this study was to estimate the number of new cells and neurons added to the dentate gyrus across the lifespan, and to compare the rate of age-associated decline in neurogenesis across species. Data from mice (Mus musculus), rats (Rattus norvegicus), lesser hedgehog tenrecs (Echinops telfairi), macaques (Macaca mulatta), marmosets (Callithrix jacchus), tree shrews (Tupaia belangeri), and humans (Homo sapiens) were extracted from twenty one data sets published in fourteen different papers. ANOVA, exponential, Weibull, and power models were fit to the data to determine which best described the relationship between age and neurogenesis. Exponential models provided a suitable fit and were used to estimate the relevant parameters. The rate of decrease of neurogenesis correlated with species longevity r = 0.769, p = 0.043), but not body mass or basal metabolic rate. Of all the cells added postnatally to the mouse dentate gyrus, only 8.5% (95% CI = 1.0% to 14.7%) of these will be added after middle age. In addition, only 5.7% (95% CI = 0.7% to 9.9%) of the existing cell population turns over from middle age onwards. Thus, relatively few new cells are added for much of an animal's life, and only a proportion of these will mature into functional neurons.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
