Chargaff第二宇称定则的Gibbs方法
A Gibbs approach to Chargaff's second parity rule
摘要：
Chargaff的第二奇偶规则（CSPR）断言短多核苷酸链的频率与互补反向链的频率相同。到目前为止，这一假设只被经验观察到，目前还没有解释它在DNA链中的存在。在这里，我们认为，CSPR是一个概率的结果对链之间的反向互补性，因为吉布斯分布与化学能之间的键满足CSPR。我们开发了一个统计测试，研究的有效性CSPR的Gibbsian假设下，我们将其应用到一个大的细菌基因组从GenBank存储库。
英文摘要：
Chargaff's second parity rule (CSPR) asserts that the frequencies of short polynucleotide chains are the same as those of the complementary reversed chains. Up to now, this hypothesis has only been observed empirically and there is currently no explanation for its presence in DNA strands. Here we argue that CSPR is a probabilistic consequence of the reverse complementarity between paired strands, because the Gibbs distribution associated with the chemical energy between the bonds satisfies CSPR. We develop a statistical test to study the validity of CSPR under the Gibbsian assumption and we apply it to a large set of bacterial genomes taken from the GenBank repository.
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