具有改进的比功率吸收的多糖衍生的磁性水凝胶：用于远程触发药物递送的潜在装置
Magnetic hydrogels derived from polysaccharides with improved specific power absorption: potential devices for remotely triggered drug delivery
摘要：
我们报告了新型铁凝胶衍生自多糖（海藻酸钠和壳聚糖）嵌入氧化铁纳米粒子原位合成，并结合热响应性聚（N-异丙基丙烯酰胺）的外部驱动的药物释放使用AC磁场。通过拉曼光谱、透射电子显微镜（TEM）和磁性测量对样品进行了表征。发现所获得的纳米颗粒具有约100. 10 nm的平均尺寸，显示磁性能非常接近的散装材料。通过功率吸收实验测量热响应，发现比功率吸收（SPA）值在100-300 W/g之间，这足以在几分钟内达到聚合物基质的低临界溶解温度（LCST）。这种快速响应使这些材料成为外部控制药物释放的良好候选者。
英文摘要：
We report on novel ferrogels derived from polysaccharides (sodium alginate and chitosan) with embedded iron oxide nanoparticles synthesized in situ and their combination with thermally responsive poly (N-isopropylacrylamide) for externally-driven drug release using AC magnetic fields. Samples were characterized by Raman spectroscopy, transmission electron microscopy (TEM) and magnetic measurements. The obtained nanoparticles were found to be of ca. 10 nm average size, showing magnetic properties very close to those of the bulk material. The thermal response was measured by power absorption experiments, finding specific power absorption (SPA) values between 100-300 W/g, which was enough for attaining the lower critical solution temperature (LCST) of the polymeric matrix within few minutes. This fast response makes these materials good candidates for externally controlled drug release.
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