釉原蛋白生物大分子简化模型中微粒形成的动力学
Kinetics of microribbon formation in a simplified model of amelogenin biomacromolecules
摘要：
我们发现，釉原蛋白分子的microribrillation形成的动力学很好地描述了一个简化的各向异性双极模型的平移和旋转扩散的组合，该模型由疏水性球形胶体颗粒和位于每个颗粒表面上的点电荷组成。胶体粒子通过标准耗尽吸引相互作用，而点电荷通过屏蔽库仑排斥相互作用。我们研究的动力学通过布朗动力学模拟的平移和旋转运动，并表明，各向异性带来的电荷显着影响的动力学途径的团簇形成和我们的简单模型捕捉到的主要特征的实验观察。
英文摘要：
We show that the kinetics of microribbon formation of amelogenin molecules is well described by a combination of translational and rotational diffusion of a simplified anisotropic bipolar model consisting of hydrophobic spherical colloid particles and a point charge located on each particle surface. The colloid particles interact via a standard depletion attraction while the point charges interact through a screened Coulomb repulsion. We study the kinetics via a Brownian dynamics simulation of both translational and rotational motions and show that the anisotropy brought in by the charge dramatically affects the kinetic pathway of cluster formation and our simple model captures the main features of the experimental observations.
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