脑内注射坐标的数学选择：在网格上编码神经解剖图谱
Algorithmic choice of coordinates for injections into the brain: encoding a neuroanatomical atlas on a grid
摘要：
给定大脑的图谱和为了绘制大脑各部分之间的连接而进行的一些注射，我们提出了一种计算注射坐标的算法。该算法被设计为以与大脑区域的分离兼容的最均匀的方式对大脑进行采样。它可以适用于其他物种的神经解剖图谱。在对应于Allen参考图集的25微米分辨率的注释上测试了计算，该图集是分层的，由209个区域组成。由此产生的注射坐标用于小鼠脑结构项目的注射方案。由于其大尺寸和分层结构，大脑皮层被处理在一个单独的算法，这是更适合其几何形状。
英文摘要：
Given an atlas of the brain and a number of injections to be performed in order to map out the connections between parts of the brain, we propose an algorithm to compute the coordinates of the injections. The algorithm is designed to sample the brain in the most homogeneous way compatible with the separation of brain regions. It can be applied to other species for which a neuroanatomical atlas is available. The computation is tested on the annotation at a resolution of 25 microns corresponding to the Allen Reference Atlas, which is hierarchical and consists of 209 regions. The resulting injection coordinates are being used for the injection protocol of the Mouse Brain Architecture project. Due to its large size and layered structure, the cerebral cortex is treated in a separate algorithm, which is more adapted to its geometry.
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