噪声可激发动力学的基因电路设计
Gene circuit designs for noisy excitable dynamics
摘要：
某些细胞过程采取活动脉冲的形式，可以用噪声驱动的可兴奋动力学来解释。在这里，我们提出了一个概述不同的基因电路架构，表现出可兴奋的脉冲蛋白质表达时，受到分子噪音。不同类型的可激发动力学可以根据导致特定可激发相空间拓扑结构的分叉结构而发生。然而，分叉结构并不与特定的电路架构相关联。因此，给定的基因电路设计可以根据系统参数维持不同类别的可激发动力学。
英文摘要：
Certain cellular processes take the form of activity pulses that can be interpreted in terms of noise-driven excitable dynamics. Here we present an overview of different gene circuit architectures that exhibit excitable pulses of protein expression, when subject to molecular noise. Different types of excitable dynamics can occur depending on the bifurcation structure leading to the specific excitable phase-space topology. The bifurcation structure is not, however, linked to a particular circuit architecture. Thus a given gene circuit design can sustain different classes of excitable dynamics depending on the system parameters.
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