arXivDaily arXiv每日学术速递 周一至周五更新
arXiv周末暂无论文更新,休息一下吧,周末愉快~~
arXiv 1102.2046math.STstat.TH
收藏

$t$的同时临界值-在非常高的维度中的测试

Simultaneous critical values for $t$-tests in very high dimensions

Hongyuan Cao, Michael R. Kosorok

摘要:

本文考虑使用$t$检验的多假设检验问题。假设观察到的数据是独立生成的条件下的基础和未知的两个状态隐藏模型。我们提出了一个渐近有效的数据驱动的过程来找到拒绝区域的临界值控制$k$ -familywise差错率($k$ -FWER),错误发现率(FDR)和错误发现比例的尾部概率(FDTP)通过使用单样本和双样本$t$ -统计。我们只需要一个有限的四阶矩加上一些非常一般的条件的平均值和方差的人口凭借中度偏差性质的$t$ -统计量。提出了一种新的备择假设比例的相合估计量。模拟研究支持我们的理论结果,并表明,功率的多个测试程序可以大大提高直接使用临界值,而不是传统的$p$值的方法。我们的方法应用于白血病癌症研究的微阵列数据分析,该研究涉及同时测试大量假设。

英文摘要:

This article considers the problem of multiple hypothesis testing using $t$-tests. The observed data are assumed to be independently generated conditional on an underlying and unknown two-state hidden model. We propose an asymptotically valid data-driven procedure to find critical values for rejection regions controlling the $k$-familywise error rate ($k$-FWER), false discovery rate (FDR) and the tail probability of false discovery proportion (FDTP) by using one-sample and two-sample $t$-statistics. We only require a finite fourth moment plus some very general conditions on the mean and variance of the population by virtue of the moderate deviations properties of $t$-statistics. A new consistent estimator for the proportion of alternative hypotheses is developed. Simulation studies support our theoretical results and demonstrate that the power of a multiple testing procedure can be substantially improved by using critical values directly, as opposed to the conventional $p$-value approach. Our method is applied in an analysis of the microarray data from a leukemia cancer study that involves testing a large number of hypotheses simultaneously.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑