人类基因组和药物发现十年后。道路（仍然）未采取
The human genome and drug discovery after a decade. Roads (still) not taken
摘要：
人类基因组的草图序列在近十年前就已可用，但编码的蛋白质组尚未得到充分的探索。我们对几个大的蛋白质家族的文献计量学分析，包括那些已知的“药物”，揭示了，即使在今天，大多数论文集中在2000年之前已知的蛋白质。很明显，生物医学研究系统的一个或多个方面严重限制了对蛋白质组“暗物质”中蛋白质的探索，尽管无偏见的遗传方法已经指出了它们的功能相关性。相对较少的基因组靶点导致了药物的批准，这也许并不奇怪。
英文摘要：
The draft sequence of the human genome became available almost a decade ago but the encoded proteome is not being explored to its fullest. Our bibliometric analysis of several large protein families, including those known to be "druggable", reveals that, even today, most papers focus on proteins that were known prior to 2000. It is evident that one or more aspects of the biomedical research system severely limits the exploration of the proteins in the 'dark matter' of the proteome, despite unbiased genetic approaches that have pointed to their functional relevance. It is perhaps not surprising that relatively few genome-derived targets have led to approved drugs.
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