VEGF-A产生的确定性和随机性以及肿瘤细胞集落的合作行为
Deterministic and stochastic aspects of VEGF-A production and the cooperative behavior of tumoral cell colony
摘要：
建立了一个研究缺氧诱导肿瘤血管生成过程的模型。该模型解释了血管内皮生长因子（VEGF）-A在调节氧摄入中所起的作用。VEGF-A受HIF-1 α浓度的动态控制。如果不被降解，HIF-1 α可以结合到称为HIF-1 β的亚基上，因此经历易位到细胞核，以发挥其适当的转录活性。这些相反的趋势之间的微妙平衡转化为不同的宏观行为的出现在相关的分子浓度，我们在这里追溯到常氧，缺氧和死亡制度。这些方面首先进行了分析，参考理想的平均场的情况。随机波动也进行了简要的讨论，并显示种子细胞单位之间的合作相互作用，竞争相同的氧气库。
英文摘要：
A model is proposed to study the process of hypoxia-induced angiogenesis in cancer cells. The model accounts for the role played by the vascular endothelial growth factor (VEGF)-A in regulating the oxygen intake. VEGF-A is dynamically controlled by the HIF-1alpha concentration. If not degraded, HIF-1alpha can bind to the subunit termed HIF-1beta and so experience translocation to the nucleus, to exert its proper transcriptional activity. The delicate balance between these opposing tendencies translates into the emergence of distinct macroscopic behaviors in terms of the associated molecular concentrations that we here trace back to normoxia, hypoxia and death regimes. These aspects are firstly analyzed with reference to the ideal mean-field scenario. Stochastic fluctuations are also briefly discussed and shown to seed a cooperative interaction among cellular units, competing for the same oxygen reservoir.
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