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arXiv 1011.3897physics.optics
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回音壁模式生物传感器中的产率增强:微流体和光学力

Yield enhancement in whispering gallery mode biosensors: microfluidics and optical forces

Kiran Khosla, Jon D. Swaim, Joachim Knittel, Warwick P. Bowen

摘要:

提出了一种微流控回音壁模式(WGM)生物传感系统,用于增强目标分子的传递和检测。将耦合到锥形光纤的微环形谐振器浸入微流体通道内,并以各种流速供应目标分子。我们通过蒙特卡罗模拟表明,传感器的流动特性和共振增强的光学力大大提高了传感时间和产量。当与扩散限制传感模式相比时,检测单个分子所需的平均时间从超过100分钟减少到不到10秒,并且对于飞摩尔浓度的分析物,该设备的总产量从不到5%提高到最大70.6%。

英文摘要:

A microfluidic whispering gallery mode (WGM) biosensing system is proposed for enhanced delivery and detection of target molecules. A microtoroid resonator coupled to a tapered optical fiber is immersed within a microfluidic channel, and supplied with target molecules at various flow rates. We show through Monte Carlo simulations that the flow characteristics and resonantly enhanced optical forces of the sensor substantially improve both the sensing time and yield. When compared to a diffusion-limited sensing modality, the average time required to detect a single molecule is reduced from more than 100 minutes to less than 10 seconds, and the overall yield of the device is enhanced from less than 5% to a maximum of 70.6% for femtomolar concentrations of analyte.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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