蛋白质相互作用网络对随机攻击的脆弱性和对恶意攻击的鲁棒性
Protein Interaction Networks are Fragile against Random Attacks and Robust against Malicious Attacks
摘要：
抵抗环境攻击的能力对所有生物的生存至关重要。我们定量分析了许多生物体的蛋白质相互作用网络对随机和恶意攻击的敏感性。我们发现，对于所有研究的生物体，随机重新布线提高了蛋白质网络的鲁棒性，因此实际网络比重新布线的替代品更脆弱。这种意想不到的脆弱性与互联网等网络的行为形成鲜明对比，互联网的鲁棒性随着随机重新布线而下降。我们将这种令人惊讶的效应追溯到蛋白质网络的模块化结构。
英文摘要：
The capacity to resist attacks from the environment is crucial to the survival of all organisms. We quantitatively analyze the susceptibility of protein interaction networks of numerous organisms to random and malicious attacks. We find for all organisms studied that random rewiring improves protein network robustness, so that actual networks are more fragile than rewired surrogates. This unexpected fragility contrasts with the behavior of networks such as the Internet, whose robustness decreases with random rewiring. We trace this surprising effect to the modular structure of protein networks.
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