波动辅助的DNA从噬菌体的排出
Fluctuation Assisted Ejection of DNA From Bacteriophage
摘要：
在一个模型计算中，讨论了热压力波动在紧密包装的DNA从蛋白质衣壳壳弹射中的作用。在排出前的平衡状态下，我们假设DNA多次折叠成一束平行的片段，以最小的自由能形成平衡构象，紧紧地压在衣壳内壁上。使用一个典型的合奏温度T，我们计算内部压力波动对一个缓慢移动或静态的衣壳地幔的弹性连续模型的折叠DNA束。据发现，波动压力的衣壳地幔从热激发的纵向声振动束可能有均方根值，这是几十个大气压的典型小噬菌体尺寸。
英文摘要：
The role of thermal pressure fluctuations in the ejection of tightly packaged DNA from protein capsid shells is discussed in a model calculation. At equilibrium before ejection we assume the DNA is folded many times into a bundle of parallel segments that forms an equilibrium conformation at minimum free energy, which presses tightly against internal capsid walls. Using a canonical ensemble at temperature T we calculate internal pressure fluctuations against a slowly moving or static capsid mantle for an elastic continuum model of the folded DNA bundle. It is found that fluctuating pressure on the capsid mantle from thermal excitation of longitudinal acoustic vibrations in the bundle may have root-mean-square values which are several tens of atmospheres for typically small phage dimensions.
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