细胞中的珍珠：了解细胞形状的线索
Pearling in cells: A clue to understanding cell shape
摘要：
肌动蛋白细胞骨架的逐渐破坏诱导细胞中的一系列结构形状变化，导致圆柱形细胞延伸转化为周期性的“珍珠”链。珠光不稳定性的定量测量给出了作为药物浓度的函数的波长的平方根行为。我们提出了一个理论，解释了这些意见的刚性的submembranous肌动蛋白壳和张力之间的相互作用，引起的边界条件设置的粘附点。该理论允许估计该支撑壳的刚度和厚度。同样的理论考虑解释了未处理细胞的一般情况下非粘附边缘的形状。
英文摘要：
Gradual disruption of the actin cytoskeleton induces a series of structural shape changes in cells leading to a transformation of cylindrical cell extensions into a periodic chain of "pearls". Quantitative measurements of the pearling instability give a square-root behavior for the wavelength as a function of drug concentration. We present a theory that explains these observations in terms of the interplay between rigidity of the submembranous actin shell and tension that is induced by boundary conditions set by adhesion points. The theory allows estimation of the rigidity and thickness of this supporting shell. The same theoretical considerations explain the shape of nonadherent edges in the general case of untreated cells.
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