电容充电驱动的脂质膜不稳定性和穿孔
Lipid membrane instability and poration driven by capacitive charging
摘要：
提出了一种新的电脉冲与脂质膜相互作用的模型。使用这个模型，我们表明，当直流电脉冲施加到绝缘脂质膜分离具有不同电导率的流体，通过膜的电容充电电流驱动电流体动力学流动，使膜不稳定。这种不稳定性是短暂的，并随着膜电荷的增加而衰减。体电导率失配在这种不稳定性中起着至关重要的作用，因为它导致膜的物理表面上的电荷积累的不同速率。只要电荷不平衡存在，由电场作用于其自身的感应自由电荷而产生的剪切应力就是非零的。因此，最不稳定的模式与膜充电时间和电流体动力学时间的比率有关。
英文摘要：
A new model for the interaction of an electric pulse with a lipid membrane is proposed. Using this model we show that when a DC electric pulse is applied to an insulating lipid membrane separating fluids with different conductivities, the capacitive charging current through the membrane drives electrohydrodynamic flow that destabilizes the membrane. The instability is transient and decays as the membrane charges. The bulk conductivity mismatch plays an essential role in this instability because it results in a different rate of charge accumulation on the membrane's physical surfaces. Shearing stresses created by the electric field acting on its own induced free charge are non-zero as long as the charge imbalance exists. Accordingly, the most unstable mode is related to the ratio of membrane charging time and the electrohydrodynamic time.
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