Biological data objects often have both of the following features: (i) they are functions rather than single numbers or vectors, and (ii) they are correlated due to phylogenetic relationships. In this paper we give a flexible statistical model for such data, by combining assumptions from phylogenetics with Gaussian processes. We describe its use as a nonparametric Bayesian prior distribution, both for prediction (placing posterior distributions on ancestral functions) and model selection (comparing rates of evolution across a phylogeny, or identifying the most likely phylogenies consistent with the observed data). Our work is integrative, extending the popular phylogenetic Brownian Motion and Ornstein-Uhlenbeck models to functional data and Bayesian inference, and extending Gaussian Process regression to phylogenies. We provide a brief illustration of the application of our method.
Hierarchical Conditioning of Diffusion Models Using Tree-of-Life for Studying Species Evolution
Virginia Tech(弗吉尼亚理工大学);Oak Ridge National Laboratory(橡树岭国家实验室);University of California, Irvine(加利福尼亚大学欧文分校);Tulane University(杜兰大学);Battelle(巴特尔公司);Duke University(杜克大学);University of North Carolina at Chapel Hill(北卡罗来纳大学教堂山分校);The Ohio State University(俄亥俄州立大学);Rensselaer Polytechnic Institute(伦斯勒理工学院)
Evaluating Phylogenetic Comparative Methods under Reticulate Evolutionary Scenarios
Texas A&M University(德克萨斯农工大学);Lakehead University(湖首大学);IISD Experimental Lakes Area(国际可持续发展研究所实验湖区);The Institute for Computational and Experimental Research in Mathematics, Brown University(布朗大学计算与实验数学研究所);RIKEN iTHEMS(理化学研究所创新智能数学科学中心)
evolSOM: an R Package for evolutionary conservation analysis with SOMs
Universidad Nacional del Litoral(国立滨海大学);Research Institute for Signals, Systems and Computational Intelligence, sinc(i)(信号、系统与计算智能研究所);CONICET(国家科学技术研究委员会)