arXivDaily arXiv每日学术速递 周一至周五更新
arXiv周末暂无论文更新,休息一下吧,周末愉快~~
arXiv 1004.4668q-bio.QMcs.LGphysics.data-anstat.ML
收藏

功能值性状的进化推断:系统发育的高斯过程回归

Evolutionary Inference for Function-valued Traits: Gaussian Process Regression on Phylogenies

Imperial College London(帝国理工学院);University of Manchester(曼彻斯特大学)

Nick S. Jones, John Moriarty

摘要:

生物学数据对象通常具有以下两个特征:(i)它们是函数而不是单个数字或向量,以及(ii)它们由于系统发育关系而相关。在本文中,我们给出了一个灵活的统计模型,这样的数据,通过结合假设从遗传学与高斯过程。我们描述了它作为一个非参数贝叶斯先验分布的使用,无论是预测(放置后验分布的祖先的功能)和模型选择(比较进化率跨越一个遗传,或确定最有可能的遗传与观察到的数据一致)。我们的工作是综合性的,将流行的系统发育布朗运动和Ornstein-Uhlenbeck模型扩展到功能数据和贝叶斯推断,并将高斯过程回归扩展到遗传学。我们提供了一个简单的说明我们的方法的应用。

英文摘要:

Biological data objects often have both of the following features: (i) they are functions rather than single numbers or vectors, and (ii) they are correlated due to phylogenetic relationships. In this paper we give a flexible statistical model for such data, by combining assumptions from phylogenetics with Gaussian processes. We describe its use as a nonparametric Bayesian prior distribution, both for prediction (placing posterior distributions on ancestral functions) and model selection (comparing rates of evolution across a phylogeny, or identifying the most likely phylogenies consistent with the observed data). Our work is integrative, extending the popular phylogenetic Brownian Motion and Ornstein-Uhlenbeck models to functional data and Bayesian inference, and extending Gaussian Process regression to phylogenies. We provide a brief illustration of the application of our method.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑