水合胶原蛋白和弹性蛋白的NMR和介电研究：离域二次弛豫的证据
NMR and dielectric studies of hydrated collagen and elastin: Evidence for a delocalized secondary relaxation
摘要：
利用介电谱和固态氘核磁共振相结合的方法，研究了结缔组织蛋白质在亚环境温度下的水合水动力学。在这个范围内，水动力学遵循阿鲁比乌斯定律。介电损耗，“两相”NMR光谱和自旋晶格弛豫时间的标度分析始终产生高斯分布的能量障碍的证据。与介电数据作为输入，随机行走模拟的大角度，准各向同性水重新取向提供了一个近似的描述的刺激回波数据水合弹性蛋白。这个次级过程发生在本质上刚性的能量景观中，但与典型的β松弛相反，它是准各向同性和离域的。从先前的NMR扩散实验推断出离域。为了强调与传统β-过程的区别，对于含水体系，这种基质解耦松弛被称为ν-过程。它强调的是，这种历史悠久的现象，“新”的过程是共享的许多非水二元玻璃，其中的组成成分表现出足够的动态对比度。
英文摘要：
Using a combination of dielectric spectroscopy and solid-state deuteron NMR, the hydration water dynamics of connective tissue proteins is studied at sub-ambient temperatures. In this range, the water dynamics follows an Arrhenius law. A scaling analysis of dielectric losses, 'two-phase' NMR spectra, and spin-lattice relaxation times consistently yield evidence for a Gaussian distribution of energy barriers. With the dielectric data as input, random-walk simulations of a large-angle, quasi-isotropic water reorientation provide an approximate description of stimulated-echo data on hydrated elastin. This secondary process takes place in an essentially rigid energy landscape, but in contrast to typical β-relaxations it is quasi-isotropic and delocalized. The delocalization is inferred from previous NMR diffusometry experiments. To emphasize the distinction from conventional β-processes, for aqueous systems such a matrix-decoupled relaxation was termed a ν-process. It is emphasized that the phenomenology of this time-honored, 'new' process is shared by many non-aqueous binary glasses in which the constituent components exhibit a sufficient dynamical contrast.
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