电火花线切割微结构钛表面间充质干细胞的成骨潜能
Bone regenerative potential of mesenchymal stem cells on a micro-structured titanium processed by wire-type electric discharge machining
摘要：
骨髓间充质干细胞在钛种植体上的移植是骨组织工程的一种新策略，已引起人们的关注。钛表面的表面支架特性对细胞的骨再生潜能起着重要作用。表面形貌和化学被认为是增加钛植入物支架性能的两个主要因素。本研究旨在评估间充质干细胞在钛金属表面的成骨基因表达。通过线放电加工，在钛合金上观察到一些粗糙度和明显的不规则特征。低氧化物层的厚度在加工过程中伴随生长。由于氧化膜的厚度和微观形貌允许细胞的mRNA表达的改善，通过线型放电加工处理的钛是基于间充质干细胞的植入物功能修复的有希望的候选者。
英文摘要：
A new strategy with bone tissue engineering by mesenchymal stem cell transplantation on titanium implant has been dawn attention. The surface scaffold properties of titanium surface play an important role in bone regenerative potential of cells. The surface topography and chemistry are postulated to be two major factors increasing the scaffold properties of titanium implants. This study aimed to evaluate the osteogenic gene expression of mesenchymal stem cells on titanium processed by wire-type electric discharge machining. Some amount of roughness and distinctive irregular features were observed on titanium processed by wire-type electric discharge machining. The thickness of suboxide layer was concomitantly grown during the processing. Since the thickness of oxide film and micro-topography allowed an improvement of mRNA expression of cells, titanium processed by wire-type electric discharge machining is a promising candidate for mesenchymal stem cell based functional restoration of implants.
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