扭转刚度如何影响半柔性链围绕球形核的缠绕过渡？
How does torsional rigidity affect the wrapping transition of a semiflexible chain around a spherical core?
摘要：
以核小体为模型，研究了半柔性链的扭转刚度对染色质的基本单位--核小体的包裹转变的影响。通过分子动力学模拟，我们发现在拓扑约束条件下，扭转效应对链的缠绕有决定性的影响。特别地，扭转应力（i）诱导缠绕/展开过渡，并且（ii）导致具有在没有拓扑约束的情况下永远不会出现的相反缠绕方向的独特复杂结构。我们进一步研究了拉伸应力对核小体模型的影响，以及扭转应力对包裹方式的独特特征影响。
英文摘要：
We investigated the effect of torsional rigidity of a semiflexible chain on the wrapping transition around a spherical core, as a model of nucleosome, the fundamental unit of chromatin. Through molecular dynamics simulation, we show that the torsional effect has a crucial effect on the chain wrapping around the core under the topological constraints. In particular, the torsional stress (i) induces the wrapping/unwrapping transition, and (ii) leads to a unique complex structure with an antagonistic wrapping direction which never appears without the topological constraints. We further examine the effect of the stretching stress for the nucleosome model, in relation to the unique characteristic effect of the torsional stress on the manner of wrapping.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
