具有伊辛变量的分子亲和力和结合的示意模型
A schematic model for molecular affinity and binding with Ising variables
摘要：
在讨论了统计物理在分子识别过程中的相关性之后，我们提出了一个基于伊辛链的配体-受体缔合的示意性模型。讨论了配体刚度增加时，亲和力的可能行为。我们还考虑了柔性受体的情况。得到了各种有趣的行为，包括一些亲和力调制后，键硬化软化。其受体的配体的亲和力取决于其刚性配置文件的细节，我们质疑的可能性编码信息的刚性以及形状。对长度为$n<8$的图案的选择性进行了详尽的研究，最后指出了与其他自旋模型，特别是自旋玻璃的联系。
英文摘要：
After discussing the relevance of statistical physics in molecular recognition processes, we present a schematic model for ligand-receptor association based on an Ising chain. We discuss the possible behaviors of the affinity when the stiffness of the ligand increases. We also consider the case of flexible receptors. A variety of interesting behaviors is obtained, including some affinity modulation upon bond hardening of softening. The affinity of a ligand for its receptor is shown to depend on the details of their rigidity profile, and we question the possibility of encoding information in the rigidities as well as in the shape. An exhaustive study of the selectivity of patterns with length $n<8$ is carried on. Connection with other spin models, in particular spin glasses is mentioned in conclusion.
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