剪切流分离微尺度手性物体
Separation of microscale chiral objects by shear flow
摘要:
我们表明,在微流体通道中的平面抛物线流动导致非运动的螺旋形细菌垂直于剪切平面漂移。净漂移的结果从优先排列的螺旋与流线,与方向,取决于螺旋的手性和剪切速率的符号。漂移与基于阻力理论的模型非常一致,并且分离是有效的(>80%)和快速的(<2s)。我们估计布朗旋转扩散对手性分离的影响,并展示了这种方法可以扩展到分离手性分子。
英文摘要:
We show that plane parabolic flow in a microfluidic channel causes nonmotile helically-shaped bacteria to drift perpendicular to the shear plane. Net drift results from the preferential alignment of helices with streamlines, with a direction that depends on the chirality of the helix and the sign of the shear rate. The drift is in good agreement with a model based on resistive force theory, and separation is efficient (>80%) and fast (<2s). We estimate the effect of Brownian rotational diffusion on chiral separation and show how this method can be extended to separate chiral molecules.
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