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arXiv 1002.3798math.PRq-bio.NCstat.ME
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具有耐火度的随机点过程的非平衡动力学

Non-equilibrium dynamics of stochastic point processes with refractoriness

Moritz Deger, Moritz Helias, Stefano Cardanobile, Fatihcan M. Atay, Stefan Rotter

摘要:

具有不应性的随机点过程经常出现在物理和生物系统的定量分析中,例如神经细胞动作电位的产生,突触处囊泡的释放和再摄取,以及检测器设备对粒子的计数。在这里,我们提出了一个扩展的更新理论来描述时变输入的点过程系综。这是通过两种状态的占用数量表示:活动和不应。这些占用数量的动态遵循一个分布延迟微分方程。特别是,我们的理论使我们能够揭示的效果不应性的时间依赖性的编码点过程的合奏率在调制的输入。我们提出了精确解,演示通用功能,如随机瞬变和振荡的阶跃响应以及共振,相位跳变和倍频的周期信号的传输。我们表明,一个大类的更新过程确实可以被视为我们分析的模型的特殊情况。因此,我们的方法代表了一个广泛适用的框架来定义和分析非平稳更新过程。

英文摘要:

Stochastic point processes with refractoriness appear frequently in the quantitative analysis of physical and biological systems, such as the generation of action potentials by nerve cells, the release and reuptake of vesicles at a synapse, and the counting of particles by detector devices. Here we present an extension of renewal theory to describe ensembles of point processes with time varying input. This is made possible by a representation in terms of occupation numbers of two states: Active and refractory. The dynamics of these occupation numbers follows a distributed delay differential equation. In particular, our theory enables us to uncover the effect of refractoriness on the time-dependent rate of an ensemble of encoding point processes in response to modulation of the input. We present exact solutions that demonstrate generic features, such as stochastic transients and oscillations in the step response as well as resonances, phase jumps and frequency doubling in the transfer of periodic signals. We show that a large class of renewal processes can indeed be regarded as special cases of the model we analyze. Hence our approach represents a widely applicable framework to define and analyze non-stationary renewal processes.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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