细胞生物学中的连续静电学
Continuum Electrostatics in Cell Biology
摘要：
最近的实验揭示了可能的纳米级静电相互作用的力产生在着丝粒染色体运动促使推测可能的模型之间的相互作用带正电的分子在着丝粒和负电荷的C-末端附近的微管的正端。在有丝分裂的复杂运动过程中，动粒如何建立和维持与微管的动态耦合以产生力的清晰画面仍然是难以捉摸的。当前的分子细胞生物学范式要求识别用于力生成的特定分子或分子几何形状。然而，它是可能的帐户内的一个经典的静电学方法在实验上已知的细胞电荷相互作用纳米距离的有丝分裂运动。这些电荷被建模为结合表面和体积连续电荷分布。有丝分裂期间细胞内pH变化的静电后果可以为有丝分裂事件提供主时钟。
英文摘要：
Recent experiments revealing possible nanoscale electrostatic interactions in force generation at kinetochores for chromosome motions have prompted speculation regarding possible models for interactions between positively charged molecules in kinetochores and negative charge on C-termini near the plus ends of microtubules. A clear picture of how kinetochores establish and maintain a dynamic coupling to microtubules for force generation during the complex motions of mitosis remains elusive. The current paradigm of molecular cell biology requires that specific molecules, or molecular geometries, for force generation be identified. However, it is possible to account for mitotic motions within a classical electrostatics approach in terms of experimentally known cellular electric charge interacting over nanometer distances. These charges are modeled as bound surface and volume continuum charge distributions. Electrostatic consequences of intracellular pH changes during mitosis may provide a master clock for the events of mitosis.
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