使用可调整大小的弹性体纳米孔检测聚苯乙烯球易位
Detection of polystyrene sphere translocations using resizable elastomeric nanopores
摘要：
可调整大小的弹性体纳米孔已被用于测量由直径为200 nm和800 nm的羧化聚苯乙烯球引起的离子电流脉冲。纳米孔代表了一种新技术，其能够通过弹性体膜的宏观致动来实现孔的纳米级膨胀。采用三种不同的孔，具有可变的施加应变、跨膜电位、颗粒浓度和球半径。描述电流脉冲幅度的理论已扩展到锥形孔几何形状。介绍了一种接近噪声阈值的数据解释的一致方法，并使用实验数据比较了几种有效的、非破坏性的孔隙尺寸计算方法。最有效的模型强调的绝对脉冲大小，这主要是由开口半径在最西端的部分大致圆锥形的孔，而不是沿整个孔长度的配置文件。实验中进行的制度，其中电渗和电泳运输是显着的。
英文摘要：
Resizable elastomeric nanopores have been used to measure pulses of ionic current caused by carboxylated polystyrene spheres of diameter 200 nm and 800 nm. The nanopores represent a novel technology which enables nanoscale resizing of a pore by macroscopic actuation of an elastomeric membrane. Three different pores were employed with variable applied strain, transmembrane potential, particle concentration and sphere radius. Theory describing current pulse magnitude has been extended to conical pore geometry. A consistent method for interpretation of data close to the noise threshold has been introduced, and experimental data has been used to compare several methods for efficient, non-destructive calculation of pore dimensions. The most effective models emphasize the absolute pulse size, which is predominantly determined by the opening radius at the narrowest part of the roughly conical pores, rather than the profile along the entire pore length. Experiments were carried out in a regime for which both electro-osmotic and electrophoretic transport are significant.
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