网络结构决定成年神经发生过程中的网络重组模式
Network structure determines patterns of network reorganization during adult neurogenesis
摘要：
新细胞在整个生命过程中产生，并通过成年神经发生过程整合到海马体中。癫痫性脑损伤引起海马体的许多结构变化，包括中间神经元的死亡和连接模式的改变。病理性神经源性小生境与异常神经发生相关，尽管网络水平的变化在癫痫发生中的作用还不清楚。在本文中，我们使用计算机模拟来研究网络环境对神经发生的结构和功能结果的影响。我们发现，具有外部刺激的小世界网络能够被活动寻求神经元以一种方式增强，这种方式增强了受刺激部位的活动，而不会改变整个网络。然而，当抑制减少或连接模式改变时，新细胞对刺激的反应更少，新细胞更有可能驱动网络进入爆发动力学。我们的研究结果表明，癫痫损伤引起的网络水平的变化可以创造一个环境，神经源性重组可以诱导或加强癫痫动力学和新细胞的异常整合。
英文摘要：
New cells are generated throughout life and integrate into the hippocampus via the process of adult neurogenesis. Epileptogenic brain injury induces many structural changes in the hippocampus, including the death of interneurons and altered connectivity patterns. The pathological neurogenic niche is associated with aberrant neurogenesis, though the role of the network-level changes in development of epilepsy is not well understood. In this paper, we use computational simulations to investigate the effect of network environment on structural and functional outcomes of neurogenesis. We find that small-world networks with external stimulus are able to be augmented by activity-seeking neurons in a manner that enhances activity at the stimulated sites without altering the network as a whole. However, when inhibition is decreased or connectivity patterns are changed, new cells are both less responsive to stimulus and the new cells are more likely to drive the network into bursting dynamics. Our results suggest that network-level changes caused by epileptogenic injury can create an environment where neurogenic reorganization can induce or intensify epileptic dynamics and abnormal integration of new cells.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
