锥形膜内含物诱导的出芽和泡状形成
Budding and vesiculation induced by conical membrane inclusions
摘要：
脂质双层中的圆锥形内含物产生膜的总体自发曲率，其取决于内含物的浓度和几何形状。例子是完整的和附着的膜蛋白，病毒和脂质结构域。我们提出了一个分析模型来研究出芽和囊泡的脂双层膜，这是基于膜的弯曲能和平移熵的夹杂物。如果夹杂物被放置在具有相似曲率半径的膜上，则它们的排斥性膜介导的相互作用被屏蔽。因此，对于高内含物密度，内含物聚集，诱导芽形成，并最终形成囊泡。已经与弯曲能量单独我们的模型允许预测芽半径。然而，在内含物诱导单个大囊泡分裂成两个较小囊泡的情况下，仅弯曲能就预测较小囊泡具有不同的尺寸，而平移熵有利于形成相等尺寸的囊泡。我们的结果与最近的计算机模拟吻合得很好。
英文摘要：
Conical inclusions in a lipid bilayer generate an overall spontaneous curvature of the membrane that depends on concentration and geometry of the inclusions. Examples are integral and attached membrane proteins, viruses, and lipid domains. We propose an analytical model to study budding and vesiculation of the lipid bilayer membrane, which is based on the membrane bending energy and the translational entropy of the inclusions. If the inclusions are placed on a membrane with similar curvature radius, their repulsive membrane-mediated interaction is screened. Therefore, for high inclusion density the inclusions aggregate, induce bud formation, and finally vesiculation. Already with the bending energy alone our model allows the prediction of bud radii. However, in case the inclusions induce a single large vesicle to split into two smaller vesicles, bending energy alone predicts that the smaller vesicles have different sizes whereas the translational entropy favors the formation of equal-sized vesicles. Our results agree well with those of recent computer simulations.
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