\emph{Vibrio harveyi}群体感应信号转导模型
A model for signal transduction during quorum sensing in \emph{Vibrio harveyi}
摘要：
我们提出了一个框架，分析在生物发光细菌\emph{Vibrio harveyi}群体感应发光调节。使用一个简化的模型，在群体感应途径的信号转导，我们确定关键的无量纲参数控制系统的响应。这些参数估计使用不同突变株的发光表型的实验数据。相应的模型预测与其他实验的结果一致，这些实验并不作为确定模型参数的输入。此外，所提出的框架导致新的可测试的预测发光表型和网络的响应不同的扰动。
英文摘要：
We present a framework for analyzing luminescence regulation during quorum sensing in the bioluminescent bacterium \emph{Vibrio harveyi}. Using a simplified model for signal transduction in the quorum sensing pathway, we identify key dimensionless parameters that control the system's response. These parameters are estimated using experimental data on luminescence phenotypes for different mutant strains. The corresponding model predictions are consistent with results from other experiments which did not serve as inputs for determining model parameters. Furthermore, the proposed framework leads to novel testable predictions for luminescence phenotypes and for responses of the network to different perturbations.
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