PAking至内皮
PAKing up to the endothelium
摘要：
血管生成重演血管的生长，血管逐渐扩张并重塑成高度组织化和定型的血管网络。在成年期，形成血管壁的内皮细胞保持其可塑性，并且可以响应生理刺激（例如缺氧、伤口愈合和组织修复、卵巢周期和妊娠）而参与新血管形成。此外，许多人类疾病和病理状况的特征在于过度的、不受控制的和异常的血管生成。涉及小Rho GT3、Rac及其下游效应物p21激活的丝氨酸/苏氨酸激酶（PAK）的信号通路最近出现为这些过程中的多效性调节剂。事实上，发现Rac和PAK调节内皮细胞生物学，如发芽、迁移、极性、增殖、管腔形成和成熟。阐明Rac/PAK分子回路将为开发旨在使人类疾病中的血管系统正常化的新治疗剂提供重要信息。
英文摘要：
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be engaged in neo-vascularization in response to physiological stimuli, such as hypoxia, wound healing and tissue repair, ovarian cycle and pregnancy. In addition, numerous human diseases and pathological conditions are characterized by an excessive, uncontrolled and aberrant angiogenesis. The signalling pathways involving the small Rho GTPase, Rac and its downstream effector the p21-activated serine/threonine kinase (PAK) had recently emerged as pleiotropic modulators in these processes. Indeed, Rac and PAK were found to modulate endothelial cell biology, such as sprouting, migration, polarity, proliferation, lumen formation, and maturation. Elucidating the Rac/PAK molecular circuitry will provide essential information for the development of new therapeutic agents designed to normalize the blood vasculature in human diseases.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
