修复蛋白引起的界面不稳定性和DNA分叉逆转
Interfacial instability and DNA fork reversal by repair proteins
摘要：
像RecG这样的修复蛋白将停滞的复制叉从DNA的压缩状态移动到解压缩状态。这里提出，在分叉处的拉链-解拉链界面的软化导致前部向解拉链侧传播。在这种情况下，一个普通的解旋酶使界面附近的压缩状态局部不稳定，并且分叉向压缩侧传播。软化的界面可以产生的芳香族相互作用，从晶体结构预测，RecG和新生断裂的碱基对之间的Y-叉。模型的数值分析也揭示了一个停止和去型运动的可能性。
英文摘要：
A repair protein like RecG moves the stalled replication fork in the direction from the zipped to the unzipped state of DNA. It is proposed here that a softening of the zipped-unzipped interface at the fork results in the front propagating towards the unzipped side. In this scenario, an ordinary helicase destabilizes the zipped state locally near the interface and the fork propagates towards the zipped side. The softening of the interface can be produced by the aromatic interaction, predicted from crystal structure, between RecG and the nascent broken base pairs at the Y-fork. A numerical analysis of the model also reveals the possibility of a stop and go type motion.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
