收缩压控制回路的去趋势波动分析
Detrended Fluctuation Analysis of Systolic Blood Pressure Control Loop
摘要：
我们使用去趋势波动分析（DFA）研究大鼠血压振荡的动力学及其反馈控制，通过分析手术前后的收缩压时间序列，中断其控制回路。我们发现，对于每种情况下，两个缩放区域之间的交叉，其特征在于指数，反映了反馈控制的性质和其操作范围。此外，我们发现了适应的证据，在血压调节的动力学手术中断其主要反馈回路后的几天。基于中枢神经系统的拮抗、双向（迷走神经和交感神经）作用的范例，我们提出了一个简单的压力稳态模型，作为两个非线性相反力量之间的平衡，成功地再现了在实际压力信号的DFA中观察到的交叉。
英文摘要：
We use detrended fluctuation analysis (DFA) to study the dynamics of blood pressure oscillations and its feedback control in rats by analyzing systolic pressure time series before and after a surgical procedure that interrupts its control loop. We found, for each situation, a crossover between two scaling regions characterized by exponents that reflect the nature of the feedback control and its range of operation. In addition, we found evidences of adaptation in the dynamics of blood pressure regulation a few days after surgical disruption of its main feedback circuit. Based on the paradigm of antagonistic, bipartite (vagal and sympathetic) action of the central nerve system, we propose a simple model for pressure homeostasis as the balance between two nonlinear opposing forces, successfully reproducing the crossover observed in the DFA of actual pressure signals.
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