An important issue in survival analysis is the investigation and the modeling of hazard rates. Within a Bayesian nonparametric framework, a natural and popular approach is to model hazard rates as kernel mixtures with respect to a completely random measure. In this paper we provide a comprehensive analysis of the asymptotic behavior of such models. We investigate consistency of the posterior distribution and derive fixed sample size central limit theorems for both linear and quadratic functionals of the posterior hazard rate. The general results are then specialized to various specific kernels and mixing measures yielding consistency under minimal conditions and neat central limit theorems for the distribution of functionals.
We consider Bayesian nonparametric inference in the right-censoring survival model, where modeling is made at the level of the hazard rate. We derive posterior limiting distributions for linear functionals of the hazard, and then for `many' functionals simultaneously in appropriate multiscale spaces. As an application, we derive Bernstein-von Mises theorems for the cumulative hazard and survival functions, which lead to asymptotically efficient confidence bands for these quantities. Further, we show optimal posterior contraction rates for the hazard in terms of the supremum norm. In medical st…
In this paper, we prove almost surely consistency of a Survival Analysis model, which puts a Gaussian process, mapped to the unit interval, as a prior on the so-called hazard function. We assume our data is given by survival lifetimes $T$ belonging to $\mathbb{R}^{+}$, and covariates on $[0,1]^d$, where $d$ is an arbitrary dimension. We define an appropriate metric for survival functions and prove posterior consistency with respect to this metric. Our proof is based on an extension of the theorem of Schwartz (1965), which gives general conditions for proving almost surely consistency in the se…
We consider the asymptotic behaviour of the marginal maximum likelihood empirical Bayes posterior distribution in general setting. First we characterize the set where the maximum marginal likelihood estimator is located with high probability. Then we provide oracle type of upper and lower bounds for the contraction rates of the empirical Bayes posterior. We also show that the hierarchical Bayes posterior achieves the same contraction rate as the maximum marginal likelihood empirical Bayes posterior. We demonstrate the applicability of our general results for various models and prior distributi…
When considering a genetic disease with variable age at onset (ex: diabetes , familial amyloid neuropathy, cancers, etc.), computing the individual risk of the disease based on family history (FH) is of critical interest both for clinicians and patients. Such a risk is very challenging to compute because: 1) the genotype X of the individual of interest is in general unknown; 2) the posterior distribution P(X|FH, T > t) changes with t (T is the age at disease onset for the targeted individual); 3) the competing risk of death is not negligible. In this work, we present a modeling of this problem…
Gaussian process models typically contain finite dimensional parameters in the covariance function that need to be estimated from the data. We study the Bayesian fixed-domain asymptotics for the covariance parameters in a universal kriging model with an isotropic Matern covariance function, which has many applications in spatial statistics. We show that when the dimension of domain is less than or equal to three, the joint posterior distribution of the microergodic parameter and the range parameter can be factored independently into the product of their marginal posteriors under fixed-domain a…
In this paper, we use the class of Wasserstein metrics to study asymptotic properties of posterior distributions. Our first goal is to provide sufficient conditions for posterior consistency. In addition to the well-known Schwartz's Kullback--Leibler condition on the prior, the true distribution and most probability measures in the support of the prior are required to possess moments up to an order which is determined by the order of the Wasserstein metric. We further investigate convergence rates of the posterior distributions for which we need stronger moment conditions. The required tail co…
Posterior distributions for community structure in sparse planted bi-section models are shown to achieve exact (resp. almost-exact) recovery, with sharp bounds for the sparsity regimes where edge probabilities decrease as $O(\log(n)/n)$ (resp. $O(1/n)$). Assuming posterior recovery, one may interpret credible sets (resp. enlarged credible sets) as asymptotically consistent confidence sets; the diameters of those credible sets are controlled by the rate of posterior concentration. If credible levels are chosen to grow to one quickly enough, corresponding credible sets can be interpreted as freq…
Statistical inference based on moment conditions and estimating equations is of substantial interest when it is difficult to specify a full probabilistic model. We propose a Bayesian flavored model selection framework based on (quasi-)posterior probabilities from the Bayesian Generalized Method of Moments (BGMM), which allows us to incorporate two important advantages of a Bayesian approach: the expressiveness of posterior distributions and the convenient computational method of Markov Chain Monte Carlo (MCMC). Theoretically we show that BGMM can achieve the posterior consistency for selecting…
In the study of life tables the random variable of interest is usually assumed discrete since mortality rates are studied for integer ages. In dynamic life tables a time domain is included to account for the evolution effect of the hazard rates in time. In this article we follow a survival analysis approach and use a nonparametric description of the hazard rates. We construct a discrete time stochastic processes that reflects dependence across age as well as in time. This process is used as a bayesian nonparametric prior distribution for the hazard rates for the study of evolutionary life tabl…
We define a novel class of additive models, called Extended Latent Gaussian Models, that allow for a wide range of response distributions and flexible relationships between the additive predictor and mean response. The new class covers a broad range of interesting models including multi-resolution spatial processes, partial likelihood-based survival models, and multivariate measurement error models. Because computation of the exact posterior distribution is infeasible, we develop a fast, scalable approximate Bayesian inference methodology for this class based on nested Gaussian, Laplace, and a…
We consider Bayesian sample size determination using a criterion that utilizes the first two moments of the expected posterior variance. We study the resulting sample size in dependence on the chosen prior and explore the success rate for bounding the posterior variance below a prescribed limit under the true sampling distribution. Compared with sample size determination based on the expected average of the posterior variance the proposed criterion leads to an increase in sample size and significantly improved success rates. Generic asymptotic properties are proven, such as an asymptotic expre…
We consider a combined state and drift estimation problem for the linear stochastic heat equation. The infinite-dimensional Bayesian inference problem is formulated in terms of the Kalman-Bucy filter over an extended state space, and its long-time asymptotic properties are studied. Asymptotic posterior contraction rates in the unknown drift function are the main contribution of this paper. Such rates have been studied before for stationary non-parametric Bayesian inverse problems, and here we demonstrate the consistency of our time-dependent formulation with these previous results building upo…
In frequentist inference, minimizing the Hellinger distance between a kernel density estimate and a parametric family produces estimators that are both robust to outliers and statistically efficienty when the parametric model is correct. This paper seeks to extend these results to the use of nonparametric Bayesian density estimators within disparity methods. We propose two estimators: one replaces the kernel density estimator with the expected posterior density from a random histogram prior; the other induces a posterior over parameters through the posterior for the random histogram. We show t…
In a general class of Bayesian nonparametric models, we prove that the posterior distribution can be asymptotically approximated by a Gaussian process. Our results apply to nonparametric exponential family that contains both Gaussian and non-Gaussian regression, and also hold for both efficient (root-n) and inefficient (non root-n) estimation. Our general approximation theorem does not rely on posterior conjugacy, and can be verified in a class of Gaussian process priors that has a smoothing spline interpretation [59, 44]. In particular, the limiting posterior measure becomes prior-free under …
We analyze the posterior contraction rates of parameters in Bayesian models via the Langevin diffusion process, in particular by controlling moments of the stochastic process and taking limits. Analogous to the non-asymptotic analysis of statistical M-estimators and stochastic optimization algorithms, our contraction rates depend on the structure of the population log-likelihood function, and stochastic perturbation bounds between the population and sample log-likelihood functions. Convergence rates are determined by a non-linear equation that relates the population-level structure to stochast…
Convergence Rates of Nonparametric Posterior Distributions
研究了后验分布的渐近性态。给出了一般的后验收敛速度定理，推广了Ghosal和Van der Vaart（2000），Shen和Wasserman（2001）以及Walker，Lijor和Prunster（2007）关于后验收敛速度的结果.我们的主要工具是Hausdorff $α$ -熵（Xing and Ranneby，2008）和先验集中度的新概念，它是Ghosal和Van der Vaart（2000）提供的通常先验集中度的轻微改进。我们将我们的结果应用到几个统计模型。
Spatial Gaussian process regression models typically contain finite dimensional covariance parameters that need to be estimated from the data. We study the Bayesian estimation of covariance parameters including the nugget parameter in a general class of stationary covariance functions under fixed-domain asymptotics, which is theoretically challenging due to the increasingly strong dependence among spatial observations. We propose a novel adaptation of the Schwartz's consistency theorem for showing posterior contraction rates of the covariance parameters including the nugget. We derive a new po…
The stratified proportional hazards model represents a simple solution to account for heterogeneity within the data while keeping the multiplicative effect on the hazard function. Strata are typically defined a priori by resorting to the values taken by a categorical covariate. A general framework is proposed, which allows for the stratification of a generic accelerated life time model, including as a special case the Weibull proportional hazard model. The stratification is determined a posteriori by taking into account that strata might be characterized by different baseline survivals as well…
In this paper, we adopt a nonparametric Bayesian approach and investigate the asymptotic behavior of the posterior distribution in continuous time and general state space semi-Markov processes. In particular, we obtain posterior concentration rates for semi-Markov kernels. For the purposes of this study, we construct robust statistical tests between Hellinger balls around semi-Markov kernels and present some specifications to particular cases, including discrete-time semi-Markov processes and finite state space Markov processes. The objective of this paper is to provide sufficient conditions o…
Quantile regression is a powerful data analysis tool that accommodates heterogeneous covariate-response relationships. We find that by coupling the asymmetric Laplace working likelihood with appropriate shrinkage priors, we can deliver posterior inference that automatically adapts to possible sparsity in quantile regression analysis. After a suitable adjustment on the posterior variance, the posterior inference provides asymptotically valid inference under heterogeneity. Furthermore, the proposed approach leads to oracle asymptotic efficiency for the active (nonzero) quantile regression coeffi…
School of Industrial Engineering, Purdue University（普渡大学工业工程学院）；Department of Statistics, Purdue University（普渡大学统计系）
We study the asymptotic consistency properties of $α$-Rényi approximate posteriors, a class of variational Bayesian methods that approximate an intractable Bayesian posterior with a member of a tractable family of distributions, the member chosen to minimize the $α$-Rényi divergence from the true posterior. Unique to our work is that we consider settings with $α> 1$, resulting in approximations that upperbound the log-likelihood, and consequently have wider spread than traditional variational approaches that minimize the Kullback-Liebler (KL) divergence from the posterior. Our primary result i…
We develop a flexible Erlang mixture model for survival analysis. The model for the survival density is built from a structured mixture of Erlang densities, mixing on the integer shape parameter with a common scale parameter. The mixture weights are constructed through increments of a distribution function on the positive real line, which is assigned a Dirichlet process prior. The model has a relatively simple structure, balancing flexibility with efficient posterior computation. Moreover, it implies a mixture representation for the hazard function that involves time-dependent mixture weights,…
In the standard Bayesian framework data are assumed to be generated by a distribution parametrized by $θ$ in a parameter space $Θ$, over which a prior distribution $π$ is given. A Bayesian statistician quantifies the belief that the true parameter is $θ_{0}$ in $Θ$ by its posterior probability given the observed data. We investigate the behavior of the posterior belief in $θ_{0}$ when the data are generated under some parameter $θ_{1},$ which may or may not be the same as $θ_{0}.$ Starting from stochastic orders, specifically, likelihood ratio dominance, that obtain for resulting distributions…
Approximate Bayesian computation allows for statistical analysis in models with intractable likelihoods. In this paper we consider the asymptotic behaviour of the posterior distribution obtained by this method. We give general results on the rate at which the posterior distribution concentrates on sets containing the true parameter, its limiting shape, and the asymptotic distribution of the posterior mean. These results hold under given rates for the tolerance used within the method, mild regularity conditions on the summary statistics, and a condition linked to identification of the true para…
In Bayesian semi-parametric analyses of time-to-event data, non-parametric process priors are adopted for the baseline hazard function or the cumulative baseline hazard function for a given finite partition of the time axis. However, it would be controversial to suggest a general guideline to construct an optimal time partition. While a great deal of research has been done to relax the assumption of the fixed split times for other non-parametric processes, to our knowledge, no methods have been developed for a gamma process prior, which is one of the most widely used in Bayesian survival analy…
Survival models are used to analyze time-to-event data in a variety of disciplines. Proportional hazard models provide interpretable parameter estimates, but proportional hazards assumptions are not always appropriate. Non-parametric models are more flexible but often lack a clear inferential framework. We propose a Bayesian tree partition model which is both flexible and inferential. Inference is obtained through the posterior tree structure and flexibility is preserved by modeling the the hazard function in each partition using a latent exponentiated Gaussian process. An efficient reversible…
This note attempts to revisit the classical results on Laplace approximation in a modern non-asymptotic and dimension free form. Such an extension is motivated by applications to high dimensional statistical and optimization problems. The established results provide explicit non-asymptotic bounds on the quality of a Gaussian approximation of the posterior distribution in total variation distance in terms of the so called \emph{effective dimension} \( p_G \). This value is defined as interplay between information contained in the data and in the prior distribution. In the contrary to prominent …
Objective: To provide guidance for the use of the main functions available in R for performing post hoc Bayesian analysis of a randomized clinical trial with a survival endpoint using proportional hazard models. Study Design and Setting: Data derived from the ALLOZITHRO trial, conducted with 465 patients after allograft to prevent pulmonary complications and allocated between azithromycin and placebo; airflow decline-free survival at 2 years after randomization was the main endpoint. Results: Despite heterogeneity in modeling assumptions, in particular for the baseline hazard (parametric or no…
