具有碱基替换、插入、删除和选择的进化模型
Evolution models with base substitutions, insertions, deletions and selection
摘要:
平行突变选择方案的进化模型的情况下,选择是伴随着碱基替换,插入和删除。假设适应度是单峰函数(即,具有一个有限的不连续性)或与参考序列的汉明距离的平滑函数。在大基因组极限下精确计算了平均适应度。在插入和缺失的情况下,进化特征取决于参考序列的选择。
英文摘要:
The evolution model with parallel mutation-selection scheme is solved for the case when selection is accompanied by base substitutions, insertions, and deletions. The fitness is assumed to be either a single-peak function (i.e., having one finite discontinuity) or a smooth function of the Hamming distance from the reference sequence. The mean fitness is exactly calculated in large-genome limit. In the case of insertions and deletions the evolution characteristics depend on the choice of reference sequence.
机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。