用于加热、温度传感和药物递送的基于碳纳米管的生物医学试剂
Carbon nanotube based biomedical agents for heating, temperature sensoring and drug delivery
摘要：
碳纳米管由于其特殊的物理和化学性质，显示出作为生物医学试剂在细胞水平上用于加热、温度传感和药物递送的有希望的潜力。用定制的材料填充碳纳米管实现了纳米级容器，其中活性物质被保护碳壳包裹。我们描述了不同的合成路线，并显示碳纳米管的结构和磁性。特别是，磁性材料的填充提供了热疗应用的潜力，而NMR活性物质的插入允许用作标记物和传感器。碳纳米管的生物医学应用的潜力是突出的热疗研究，证明其适用于局部原位加热。此外，我们已经证明，通过碳包裹的纳米级温度计和填充抗癌药物的非侵入性温度控制是可能的。
英文摘要：
Due to their extraordinary physical and chemical properties carbon nanotubes reveal a promising potential as biomedical agents for heating, temperature sensoring and drug delivery on the cellular level. Filling carbon nanotubes with tailored materials realises nanoscaled containers in which the active content is encapsulated by a protecting carbon shell. We describe different synthesis routes and show the structural and magnetic properties of carbon nanotubes. In particular, the filling with magnetic materials offers the potential for hyperthermia applications while the insertion of NMR active substances allows the usage as markers and sensors. The potential of carbon nanotubes for biomedical applications is highlighted by hyperthermia studies which prove their applicability for local in-situ heating. In addition we have shown that a non-invasive temperature control by virtue of a carbon-wrapped nanoscaled thermometer and filling with anti-cancer drugs is possible.
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