Dendritic cells are the crime scene investigators of the human immune system. Their function is to correlate potentially anomalous invading entities with observed damage to the body. The detection of such invaders by dendritic cells results in the activation of the adaptive immune system, eventually leading to the removal of the invader from the host body. This mechanism has provided inspiration for the development of a novel bio-inspired algorithm, the Dendritic Cell Algorithm. This algorithm processes information at multiple levels of resolution, resulting in the creation of information granules of variable structure. In this chapter we examine the multi-faceted nature of immunology and how research in this field has shaped the function of the resulting Dendritic Cell Algorithm. A brief overview of the algorithm is given in combination with the details of the processes used for its development. The chapter is concluded with a discussion of the parallels between our understanding of the human immune system and how such knowledge influences the design of artificial immune systems.
School of Computer Science, University of Nottingham（诺丁汉大学计算机学院）
Dendritic cells are antigen presenting cells that provide a vital link between the innate and adaptive immune system, providing the initial detection of pathogenic invaders. Research into this family of cells has revealed that they perform information fusion which directs immune responses. We have derived a Dendritic Cell Algorithm based on the functionality of these cells, by modelling the biological signals and differentiation pathways to build a control mechanism for an artificial immune system. We present algorithmic details in addition to experimental results, when the algorithm was appli…
School of Computer Science, University of Nottingham（诺丁汉大学计算机科学学院）
Dendritic Cells (DCs) are innate immune system cells which have the power to activate or suppress the immune system. The behaviour of human of human DCs is abstracted to form an algorithm suitable for anomaly detection. We test this algorithm on the real-time problem of port scan detection. Our results show a significant difference in artificial DC behaviour for an outgoing portscan when compared to behaviour for normal processes.
School of Computer Science, University of Nottingham（诺丁汉大学计算机科学学院）
Artificial immune systems have previously been applied to the problem of intrusion detection. The aim of this research is to develop an intrusion detection system based on the function of Dendritic Cells (DCs). DCs are antigen presenting cells and key to activation of the human immune system, behaviour which has been abstracted to form the Dendritic Cell Algorithm (DCA). In algorithmic terms, individual DCs perform multi-sensor data fusion, asynchronously correlating the the fused data signals with a secondary data stream. Aggregate output of a population of cells, is analysed and forms the ba…
School of Computer Science, University of Nottingham（诺丁汉大学计算机学院）；Hewlett Packard Labs（惠普实验室）
The Dendritic Cell Algorithm (DCA) is inspired by the function of the dendritic cells of the human immune system. In nature, dendritic cells are the intrusion detection agents of the human body, policing the tissue and organs for potential invaders in the form of pathogens. In this research, and abstract model of DC behaviour is developed and subsequently used to form an algorithm, the DCA. The abstraction process was facilitated through close collaboration with laboratory- based immunologists, who performed bespoke experiments, the results of which are used as an integral part of this algorit…
Dendritic Computing with Multi-Gate Ferroelectric Field-Effect Transistors
School of Electrical Engineering \& Computer Science, The Pennsylvania State University, University Park, 16802, PA, USA；Department of Electrical Engineering, University of Notre Dame, Notre Dame, 46556, IN, USA
University of Nottingham（诺丁汉大学）；Hewlett-Packard Labs plc（惠普实验室股份有限公司）
Dendritic cells are antigen presenting cells that provide a vital link between the innate and adaptive immune system. Research into this family of cells has revealed that they perform the role of coordinating T-cell based immune responses, both reactive and for generating tolerance. We have derived an algorithm based on the functionality of these cells, and have used the signals and differentiation pathways to build a control mechanism for an artificial immune system. We present our algorithmic details in addition to some preliminary results, where the algorithm was applied for the purpose of …
School of Computer Science University of Nottingham（诺丁汉大学计算机科学学院）
As one of the newest members in the field of artificial immune systems (AIS), the Dendritic Cell Algorithm (DCA) is based on behavioural models of natural dendritic cells (DCs). Unlike other AIS, the DCA does not rely on training data, instead domain or expert knowledge is required to predetermine the mapping between input signals from a particular instance to the three categories used by the DCA. This data preprocessing phase has received the criticism of having manually over-?tted the data to the algorithm, which is undesirable. Therefore, in this paper we have attempted to ascertain if it i…
School of Computer Science, University of Nottingham（诺丁汉大学计算机科学学院）
Artificial immune systems, more specifically the negative selection algorithm, have previously been applied to intrusion detection. The aim of this research is to develop an intrusion detection system based on a novel concept in immunology, the Danger Theory. Dendritic Cells (DCs) are antigen presenting cells and key to the activation of the human signals from the host tissue and correlate these signals with proteins know as antigens. In algorithmic terms, individual DCs perform multi-sensor data fusion based on time-windows. The whole population of DCs asynchronously correlates the fused sign…
In this paper, we present an approach for predicting trust links between peers in social media, one that is grounded in the artificial intelligence area of multiagent trust modeling. In particular, we propose a data-driven multi-faceted trust modeling which incorporates many distinct features for a comprehensive analysis. We focus on demonstrating how clustering of similar users enables a critical new functionality: supporting more personalized, and thus more accurate predictions for users. Illustrated in a trust-aware item recommendation task, we evaluate the proposed framework in the context…
School of Computer Science, University of Nottingham（诺丁汉大学计算机科学学院）
As one of the newest members in Artificial Immune Systems (AIS), the Dendritic Cell Algorithm (DCA) has been applied to a range of problems. These applications mainly belong to the field of anomaly detection. However, real-time detection, a new challenge to anomaly detection, requires improvement on the real-time capability of the DCA. To assess such capability, formal methods in the research of rea-time systems can be employed. The findings of the assessment can provide guideline for the future development of the algorithm. Therefore, in this paper we use an interval logic based method, named…
School of Computer Science, University of Nottingham（诺丁汉大学计算机学院）
The human immune system has numerous properties that make it ripe for exploitation in the computational domain, such as robustness and fault tolerance, and many different algorithms, collectively termed Artificial Immune Systems (AIS), have been inspired by it. Two generations of AIS are currently in use, with the first generation relying on simplified immune models and the second generation utilising interdisciplinary collaboration to develop a deeper understanding of the immune system and hence produce more complex models. Both generations of algorithms have been successfully applied to a va…
University of Toronto（多伦多大学）；Australian National University（澳大利亚国立大学）
The societal and ethical implications of the use of opaque artificial intelligence systems for consequential decisions, such as welfare allocation and criminal justice, have generated a lively debate among multiple stakeholder groups, including computer scientists, ethicists, social scientists, policy makers, and end users. However, the lack of a common language or a multi-dimensional framework to appropriately bridge the technical, epistemic, and normative aspects of this debate prevents the discussion from being as productive as it could be. Drawing on the philosophical literature on the nat…
The field of artificial intelligence (AI) represents an enormous endeavour of humankind that is currently transforming our societies down to their very foundations. Its task, building truly intelligent systems, is underpinned by a vast array of subfields ranging from the development of new electronic components to mathematical formulations of highly abstract and complex reasoning. This breadth of subfields renders it often difficult to understand how they all fit together into a bigger picture and hides the multi-faceted, multi-layered conceptual structure that in a sense can be said to be wha…
Broadening the perspective for sustainable AI: Comprehensive sustainability criteria and indicators for AI systems
Institute for Ecological Economy Research（生态经济研究所）；Technische Universität Berlin（柏林工业大学）；University of Kassel（卡塞尔大学）；Birds on Mars GmbH（Birds on Mars有限公司）；University of Münster（明斯特大学）；AlgorithmWatch gGmbH（AlgorithmWatch非营利有限责任公司）
