双态闪光分子泵
Two-state flashing molecular pump
摘要：
在这里，我们研究的泵送装置能够保持密度梯度和跨膜的粒子通量。其驱动机制是基于在热波动存在下由随机电报过程提供动力的闪烁棘轮效应。与布朗马达不同，两个储层边界处的浓度需要作为边界条件来实现。二分闪烁的停留跃迁速率与ATP分子的结合和水解有关。对模型进行了精确求解和探索。讨论了泵的能量学，并在生物尺度内调整了相关参数值。
英文摘要：
Here we study a pumping device capable of maintaining a density gradient and a flux of particles across a membrane. Its driving mechanism is based on the flashing ratchet effect powered by the random telegraph process in the presence of thermal fluctuations. Unlike Brownian motors, the concentrations at both reservoir boundaries need to be implemented as boundary conditions. The residence transition rates of the dichotomic flashing are related to the binding and hydrolysis of ATP molecules. The model is exactly solved and explored. The pump energetics is discussed and the relevant parameter values are tuned within a biological scale.
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