淀粉样蛋白纤维化过程中的各向同性相变
Isotropic-nematic phase transition in amyloid fibrilization
摘要：
本文对淀粉样蛋白纤维溶液的各向同性相变和相分离进行了理论研究。借用热力学模型中采用的圆柱形胶束的研究，我们调查的纤维长度分布和相行为的变化相对于蛋白质浓度，纤维的刚性，和结合能的变化。然后，我们将我们的理论研究结果与在母鸡溶菌酶原纤维溶液中观察到的有序性联系起来。
英文摘要：
We carry out a theoretical study on the isotropic-nematic phase transition and phase separation in amyloid fibril solutions. Borrowing the thermodynamic model employed in the study of cylindrical micelles, we investigate the variations in the fibril length distribution and phase behavior with respect to changes in the protein concentration, fibril's rigidity, and binding energy. We then relate our theoretical findings to the nematic ordering observed in Hen Lysozyme fibril solution.
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