酶逻辑门中的模拟噪声抑制
Analog Noise Reduction in Enzymatic Logic Gates
摘要：
在这项工作中，我们从实验和理论上证明，通过一个单一的酶逻辑门的模拟噪声产生可以显着减少，几乎没有输入噪声放大产生门操作。这是通过在使用具有比主要底物低得多的亲和力的共底物时利用酶的特异性来实现的。在这些条件下，我们得到一个可以忽略不计的增加，从逻辑门的噪声输出相比，输入噪声水平。与逻辑门的实验实现与酶辣根过氧化物酶使用过氧化氢和两种不同的共底物，2，2 '-连氮基-双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）和亚铁氰化物，具有非常不同的速率常数证实了我们的一般理论结论。
英文摘要：
In this work we demonstrate both experimentally and theoretically that the analog noise generation by a single enzymatic logic gate can be dramatically reduced to yield gate operation with virtually no input noise amplification. This is achieved by exploiting the enzyme's specificity when using a co-substrate that has a much lower affinity than the primary substrate. Under these conditions, we obtain a negligible increase in the noise output from the logic gate as compared to the input noise level. Experimental realizations of the AND logic gate with the enzyme horseradish peroxidase using hydrogen peroxide and two different co-substrates, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) and ferrocyanide, with vastly different rate constants confirmed our general theoretical conclusions.
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