评《重测双重阻碍》
Comments on "Remeasuring the Double Helix"
摘要：
Mathew-Fenn等人（Science（2008）322，446-9）测量了短DNA的端到端距离，并得出结论，双螺旋的几个连续转角中的拉伸波动应该是强烈相关的。我认为，这一结论是基于不正确的假设，特别是，在一个简单的治疗排除体积效应的报告标签。与提交人的声称相反，他们的结论没有得到其他数据的支持。
英文摘要：
Mathew-Fenn et al. (Science (2008) 322, 446-9) measured end-to-end distances of short DNA and concluded that stretching fluctuations in several consecutive turns of the double helix should be strongly correlated. I argue that this conclusion is based on incorrect assumptions, notably, on a simplistic treatment of the excluded volume effect of reporter labels. Contrary to the author's claim, their conclusion is not supported by other data.
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